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Fully integrated approach: an alternative solution of coupling a GIS and diffuse pollution models

S. LIU,R.E. BRAZIER,A. L. HEATHWAITE,W. LIU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 4,   Pages 616-623 doi: 10.1007/s11783-013-0589-x

Abstract: analysis of spatially referred information, GIS has been recognized as a method to aid the modeling of diffuseA common question in integrating diffuse pollution models and GIS is to choose a suitable coupling approach, in which the feature of diffuse pollution models should be taken into account.In this paper, we report on our experience in coupling a distributed diffuse pollution model with a GISexecution and more robust than loose and tight coupling approaches and is suitable for distributed diffuse

Keywords： diffuse pollution     GIS     modeling     nutrients     phosphorus    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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The issues related to determination of site specific design ground motion for nuclear power plants in China

Li Xiaojun,He Qiumei,Hou Chunlin

Strategic Study of CAE 2013, Volume 15, Issue 4,   Pages 75-82

Abstract: the uncertainty of ground motion attenuation relation and the ground motion attenuation relation of diffuseearthquake; the differences were discussed between the computed results from the probabilistic methodand the approaches of the diffuse earthquakes and tectonic earthquakes in the deterministic method,earthquake is a special problem considered; b. the controlling effects of the computed results fromearthquake, but in relatively strong seismicity areas, site specific design ground motion parameters

Keywords： design ground motion     deterministic method     probabilistic method     ground motion attenuation relation     diffuseearthquake     uncertainty    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: achieved 40%–50% long-term complete response in relapsed or refractory diffuse

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German

Muhammad WASEEM, Frauke KACHHOLZ, Jens TRÄNCKNER

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 420-431 doi: 10.15302/J-FASE-2018243

Abstract:

Various process-based models are extensively being used to analyze and forecast catchment hydrology and water quality. However, it is always important to select the appropriate hydrological and water quality modeling tools to predict and analyze the watershed and also consider their strengths and weaknesses. Different factors such as data availability, hydrological, hydraulic, and water quality processes and their desired level of complexity are crucial for selecting a plausible modeling tool. This review is focused on suitable model selection with a focus on desired hydrological, hydraulic and water quality processes (nitrogen fate and transport in surface, subsurface and groundwater bodies) by keeping in view the typical lowland catchments with intensive agricultural land use, higher groundwater tables, and decreased retention times due to the provision of artificial drainage. In this study, four different physically based, partially and fully distributed integrated water modeling tools, SWAT (soil and water assessment tool), SWIM (soil and water integrated model), HSPF (hydrological simulation program– FORTRAN) and a combination of tools from DHI (MIKE SHE coupled with MIKE 11 and ECO Lab), have been reviewed particularly for the Tollense River catchment located in North-eastern Germany. DHI combined tools and SWAT were more suitable for simulating the desired hydrological processes, but in the case of river hydraulics and water quality, the DHI family of tools has an edge due to their integrated coupling between MIKE SHE, MIKE 11 and ECO Lab. In case of SWAT, it needs to be coupled with another tool to model the hydraulics in the Tollense River as SWAT does not include backwater effects and provision of control structures. However, both SWAT and DHI tools are more data demanding in comparison to SWIM and HSPF. For studying nitrogen fate and transport in unsaturated, saturated, and river zone, HSPF was a better model to simulate the desired nitrogen transformation and transport processes. However, for nitrogen dynamics and transformations in shallow streams, ECO Lab had an edge due its flexibility for inclusion of user-desired water quality parameters and processes. In the case of SWIM, most of the input data and governing equations are similar to SWAT but it does not include water bodies (ponds and lakes), wetlands and drainage systems. In this review, only the processes that were needed to simulate the Tollense River catchment were considered, however the resulted model selection criteria can be generalized to other lowland catchments in Australia, North-western Europe and North America with similar complexity.

Keywords： diffuse pollution     ECO Lab     HSPF     lowland catchment     MIKE 11     MIKE SHE     modeling tools     SWAT     SWIM     Tollense River    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: second-generation anti-CD19 CAR bearing 4-1BB costimulatory molecule, for the treatment of patients with refractory diffuse

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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Rethinking of geological disaster control at the anniversary of the Wenchuan Earthquake

Lu Yaoru

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 36-43

Abstract:

The big Wenchuan Earthquake has passed for a year, but the huge disastercaused by the earthquake cannot be forgotten yet.The scientific development view should be better carried out and the earthquake mechanism should be analyzed

Keywords： Wenchuan Earthquake     the earthquake history of Chuan-Dian area     geological disaster     earthquake mechanism    

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Prediction and thoughts of the Wenchuan large earthquake

Geng Qingguo

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 123-128

Abstract:

According to many years of earthquake prediction exploring work basedon analysis of drought -earthquake relations and ordered strong earthquake activities and the methodthe Sichuan Abazhou area, and revealed the main points of the "Urgent advice to enhance strong earthquake

Keywords： Wenchuan Large Earthquake prediction     drought-earthquake relations     strong earthquake activities order    

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The phenomena based on the before Wenchuan Earthquake, the characteristic of large scale and deep layeron dynamic force of earthquake occurrence has been recognized

Xu Shaoxie

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 16-18

Abstract: text-align: justify;">The characteristic of large scale and deep layer on dynamic force of Wenchuan EarthquakeThe seismicity before Wenchuan Earthquake of May 12, 2008 has been studied, by using the data from 1977activity enhanced in deep layer, are important phenomena before Wenchuan Earthquake.Such characteristics have already been found in the phenomena before Tangshan Earthquake in 1976.Since the disaster of a great earthquake is very serious, it should be enhanced to collect and study

Keywords： Wenchuan Earthquake     the characteristic of large scale and deep layer on dynamic force of earthquakeoccurrence     earthquake prediction    

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Destructive Earthquakes Are Predictable——The Physical Model of Earthquake Gestation and the Signal of

Sun Wei

Strategic Study of CAE 2007, Volume 9, Issue 7,   Pages 7-17

Abstract:

What is discussed here is that the earthquake precursor have their ownAn analytic method is brought forward for tracing the information on the warning signs of an earthquakeAlso, earthquake prediction is preactically divided into stages, making it possible to realize the predicting

Keywords： destructive earthquake     quake-breeding physical model     signals before an earthquake     earthquake precursor    

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The scientific faith that earthquake is predictable should be insisted—the successful prediction of threestrong aftershocks of Wenchuan Earthquake

Wang Chengmin

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 107-110

Abstract:

Is earthquake predictable?This question has been discussed a lot by earthquake researchers and common people after the WenchuanEarthquake.The specialists in Chinese Earthquake Prediction Consultation Committee started the aftershockprediction research after the earthquake to support emergency rescue and disaster relief with practicalon May 18 in Jiangyou, M 6.4 earthquake on May 25 in Qingchuan and M 6.1 earthquake on August 1 in Beichuan

Keywords： Wenchuan Earthquake     aftershock of Wenchuan Earthquake     earthquake short -impending prediction    

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Statistic and review of China’s earthquake prediction score

Gao Jianguo

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 129-131

Abstract:

Earthquake is difficult to forecast, but it doesn't happen withoutsigns or unknown,our country has the case summary for every large earthquake.Statistics clearly showmiddle -term, short -term or imminent earthquakes in the last 40 years.Therefore, success in Chinese earthquakeprediction could not be denied only because of failure in Wenchuan Earthquake prediction.China'searthquake prediction score should be positive,and Wenchuan Earthquake is not a "strange shock&

Keywords： earthquake     earthquake prediction     nearly 30 years’earthquake prediction statistics in china    

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Short-term and impending precursor of sand layer stress in Wenchuan Earthquake

Wang Baoyu,Tong Xiaohui,Sun Xiaoming ,Sun Wei

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 146-152

Abstract:

An earthquake preparation physical model was established based on observationdata of sand layer stress instrument in Changping and Xiji, Beijing, earthquake precursor in the past30 years observed by this instrument and precursor of Indonesia Earthquake (M =8.7) on December 26,2004.The short-term and impending precursor of Wenchuan Earthquake recorded by the sand layer stressinfrared and other testing methods in the aspect of time, had very obvious characters of impending earthquake

Keywords： Wenchuan Earthquake     sand layer stress instrument     earthquake preparation physical model of sand layerstress     impending earthquake signal    

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Lessons learnt from the great Sichuan Wenchuan Earthquake

Xie Lili

Strategic Study of CAE 2009, Volume 11, Issue 6,   Pages 28-35

Abstract: text-align: justify;">This paper presents the major lessons learnt from the recently occurred devastating earthquakeIt discussed some bottle-neck questions existing in the current earthquake disaster prevention work oflow quality construction in both rural and town area, seismic hazard assessment and seismic zoning, earthquakeinduced geological hazard, and earthquake prediction etc., and pointed out that the civil engineeringprevention method is the best choice for the solution of reducing earthquake losses and mitigating earthquake

Keywords： Wenchuan Earthquake     earthquake prevention and mitigation     prevention first     civil engineeringThoughts on    

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Neural network control for earthquake structural vibration reduction using MRD

Khaled ZIZOUNI, Leyla FALI, Younes SADEK, Ismail Khalil BOUSSERHANE

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 5,   Pages 1171-1182 doi: 10.1007/s11709-019-0544-4

Abstract: Structural safety of building particularly that are intended for exposure to strong earthquake loads

Keywords： MR damper     semi-active control     earthquake vibration     neural network     linear quadratic control    

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Title Author Date Type Operation

Fully integrated approach: an alternative solution of coupling a GIS and diffuse pollution models

S. LIU,R.E. BRAZIER,A. L. HEATHWAITE,W. LIU

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

The issues related to determination of site specific design ground motion for nuclear power plants in China

Li Xiaojun,He Qiumei,Hou Chunlin

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German

Muhammad WASEEM, Frauke KACHHOLZ, Jens TRÄNCKNER

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

Journal Article

Rethinking of geological disaster control at the anniversary of the Wenchuan Earthquake

Lu Yaoru

Journal Article

Prediction and thoughts of the Wenchuan large earthquake

Geng Qingguo

Journal Article

The phenomena based on the before Wenchuan Earthquake, the characteristic of large scale and deep layeron dynamic force of earthquake occurrence has been recognized

Xu Shaoxie

Journal Article

Destructive Earthquakes Are Predictable——The Physical Model of Earthquake Gestation and the Signal of

Sun Wei

Journal Article

The scientific faith that earthquake is predictable should be insisted—the successful prediction of threestrong aftershocks of Wenchuan Earthquake

Wang Chengmin

Journal Article

Statistic and review of China’s earthquake prediction score

Gao Jianguo

Journal Article

Short-term and impending precursor of sand layer stress in Wenchuan Earthquake

Wang Baoyu,Tong Xiaohui,Sun Xiaoming ,Sun Wei

Journal Article

Lessons learnt from the great Sichuan Wenchuan Earthquake

Xie Lili

Journal Article

Neural network control for earthquake structural vibration reduction using MRD

Khaled ZIZOUNI, Leyla FALI, Younes SADEK, Ismail Khalil BOUSSERHANE

Journal Article